Journal
BREAST CANCER RESEARCH
Volume 10, Issue 4, Pages -Publisher
BMC
DOI: 10.1186/bcr2111
Keywords
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Funding
- National Breast Cancer Foundation
- Griffith University Postgraduate Scholarship
- Endeavour International Postgraduate Research Scholarship
- Suncorp-Metway Ride-for-Research
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The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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