Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 1, Pages 8-15Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7425-z
Keywords
cell cycle; quiescence; terminal differentiation; proliferative senescence; cyclins; cyclin-dependent kinase inhibitors
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
- Telethon [GGP05006] Funding Source: Medline
Ask authors/readers for more resources
Tissue repair and regeneration are very complex biological events, whose successful attainment requires far more than mere cell division. However, almost unavoidably they entail cell proliferation as a fundamental premise. Full regeneration or repair cannot be achieved without replacing cells lost to disease or injury, replacement that can only take place via proliferation of surviving cells. This review endeavors to outline the molecular bases of exit from and reentry into the cell cycle. In recent years, the decision to proliferate or not has been seen as mostly the concern of cyclins and cyclin-dependent kinases. This account tries to show that cell cycle inhibitors are as important as the positive regulators in the making of this decision. Finally, the authors wish to suggest that the molecular knowledge of the cell cycle can be harnessed to the benefit of many aspects of regenerative medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available