Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 307, Issue 1-2, Pages 141-147Publisher
SPRINGER
DOI: 10.1007/s11010-007-9593-4
Keywords
PDGF; NF-kappa B; glioblastoma
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NF-kappa B is a family of transcription factors that have been shown to be elevated in a variety of tumor types and in some cases central to their survival and growth. Here we present evidence that U-87 MG and U-118 MG growth is regulated by NF-kappa B and controlled by PDGF. NF-kappa B activity was suppressed by a dominant negative mutant of the human PDGF type beta receptor and PDGF-B chain neutralizing antibodies. Creation of cell lines that had inducible expression of shRNAs directed against either c-Rel or RelA inhibited growth almost 90% indicating that NF-kappa B plays a central role in glioblastoma growth.
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