Journal
NATURE GENETICS
Volume 40, Issue 1, Pages 29-31Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2007.52
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068875] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH078075] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [Z01AG000933, ZIAAG000933] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM68875] Funding Source: Medline
- NIMH NIH HHS [MH078075] Funding Source: Medline
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We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04x10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18 - 1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
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