Journal
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
Volume 33, Issue 10, Pages 3417-3422Publisher
KOREAN CHEMICAL SOC
DOI: 10.5012/bkcs.2012.33.10.3417
Keywords
Nucleosides; Nitroindole; Silver nanoparticles; Antiviral activity
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A new method for the construction of 3-aminoindole nucleosides of 2-acetamido-2-deoxy-D-glucose based is presented. Nitration and acetylation of the indole nucleosides by acetic anhydride-nitric acid mixture followed by reduction using silver catalyst (SNSM) impregnated on silica gel, afforded the corresponding amino indole nucleosides. The nucleosides were tested for antiviral activity against hepatitis B virus (HBV) to show different degrees of antiviral activities or inhibitory actions.
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