Journal
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
Volume 32, Issue 1, Pages 53-58Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.5012/bkcs.2011.32.1.53
Keywords
ZnS:Mn nanocrystal; Amino acid capping; Cytotoxicity; E. coli; Human cells
Categories
Funding
- Korean Government (MOEHRD) [KRF-2008-331-E00108]
- GRRC program, Gyeonggi Province [GRRC-Dankook-2010-B02]
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Cysteine and histidine-capped water-dispersible ZnS:Mn nanocrystals (ZnS:Mn-Cys and ZnS:Mn-His) were synthesized and their effects on E. coli and human cells were investigated. Particle sizes of these nanocrystals were found from HR-TEM images to be 3.5 nm and 4.0 nm, respectively. Their solution photoluminescence spectra showed identical broad emission peaks at 580 rim. ZnS:Mn-His significantly suppressed the growth of E. coli at 100 mu g/mL and 1 mg/mL concentrations, something not observed with ZnS:Mn-Cys. Consistent with this, greater inhibition of cell proliferation and viability were observed in HEK293 and IMR90 cells in ZnS:Mn-His at 100 mu g/mL and 1 mg/mL concentrations.
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