Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and Their Biological Activity

A simple and efficient synthesis of various alpha-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, H-1, C-13- and P-31-NMR spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the alpha-carbon.