Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 87, Issue 5, Pages 609-613Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20140008
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24310160, 25750386]
- Grants-in-Aid for Scientific Research [25750386] Funding Source: KAKEN
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Kurahamide, a new dolastatin 13 analog, was isolated from a marine cyanobacterial assemblage, consisting mostly of Lyngbya sp. Its gross structure was elucidated by spectroscopic analysis, and the stereochemistries were assigned based on a chiral HPLC analysis of hydrolysis products. Kurahamide strongly inhibited elastase and chymotypsin in vitro. In addition, kurahamide moderately inhibited the growth of human cancer cells, including HeLa and HL60 cells.
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