Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 87, Issue 11, Pages 1231-1234Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20140188
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Funding
- National Museum of Marine Biology and Aquarium
- Ministry of Science and Technology, Taiwan [MOST 103-2320-B-291-001-MY3]
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Two new polyacetylenic compounds, callysponynes A (1) and B (2), were isolated from the marine sponge Callyspongia sp. The structures of the new metabolites were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Moreover, the absolute configuration of 1 was determined by Mosher's method. Compounds 1 and 2 exhibited cytotoxic activity in vitro against MOLT-4, K-562, and HCT 116 cancer cell lines.
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