4.4 Article

Highly Regioselective Double Hydrothiolation of Terminal Acetylenes with Thiols Catalyzed by Palladium Diacetate

Journal

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 84, Issue 4, Pages 413-415

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20100311

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan [19350095]
  2. Japan Society for the Promotion of Science (JSPS)
  3. Grants-in-Aid for Scientific Research [23550057, 19350095] Funding Source: KAKEN

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Treatment of terminal acetylenes 1 with two equivalents of thiols 2 in the presence of Pd(OAc)(2) catalyst and H2O causes regioselective double hydrothiolation of 1, leading to the corresponding dithioketals 3 in moderate to good yields.

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