Simplexins J-O, Eunicellin-Based Diterpenoids from a Dongsha Atoll Soft Coral Klyxum simplex

Six new eunicellin-based diterpenoids, simplexins J-O (1-6), were isolated from a Dongsha Atoll soft coral, Klyxum simplex. The structures of these compounds were established by detailed spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 4-6 have been found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells.