Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 84, Issue 6, Pages 653-655Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20100324
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- National Science Council of Taiwan [NSC 99-2320-B-291-001]
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Two new cembranoids, locrassolides A (1) and B (2), along with three known metabolites 3-5 were isolated from the soft coral Lobophytum crassum. None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines (CCRF-CEM and DLD-1). Metabolite 3 was shown to significantly inhibit the accumulation of the proinflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells.
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