4.4 Article

Klysimplexins U-X, Eunicellin-Based Diterpenoids from the Cultured Soft Coral Klyxum simplex

Journal

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 84, Issue 11, Pages 1237-1242

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20110156

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Funding

  1. National Museum of Marine Biology and Aquarium [NMM98001]
  2. National Science Council of Taiwan [NSC-98-2113-M-110-002-MY3]
  3. Ministry of Education of Taiwan [98C031702]

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New eunicellin-based diterpenoids, klysimplexins U-X (1-4), were isolated from a cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly in 1 D and 2D NMR experiments. The absolute configuration of 2 was determined by Mosher's method. Compounds 1 and 2 are the first example of 4-oxygenated eunicellin-type diterpenes isolated from soft corals of this genus.

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