Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 83, Issue 6, Pages 678-682Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20090263
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Funding
- Ministry of Education [97C031702]
- National Science Council of Taiwan [NSC 98-2113-M-110-002-MY3]
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Two new natural products, the oppositane-type sesquiterpenoids leptocladolins A and B (1 and 2), along with two known compounds 1 beta-hydroxy-6 alpha-acetoxyeudesm-4(15)-ene (3) and 1 beta,6 alpha-dihydroxyeudesm-4(15)-ene (4) were obtained from a Formosan soft coral Sinularia leptoclados. The relative structures of 1 and 3 were confirmed by X-ray diffraction analysis. The absolute structures of 1 and 3 were determined by the Mosher's method. It was found that 4 significantly inhibited the upregulation of pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells.
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