Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 81, Issue 10, Pages 1304-1307Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.81.1304
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Funding
- Ministry of Education [96CO31702]
- National Science Council of Taiwan [NSC 95-2113-M-110-011-MY3]
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Five new polyoxygenated steroids 1-5 have been isolated from a Formosan soft coral Sinularia facile. The structures of new metabolites were elucidated on the basis of extensive spectroscopic analysis and cytotoxic activity of 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Metabolite 4 has been shown to exhibit weak cytotoxicity against Hell G2, Hep G3B. MDA-MB-231, and Ca9-22 cancer cell lines.
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