Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 10, Pages 692-703Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2634
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Inflammation is a multicomponent response to tissue stress, injury and infection, and a crucial point of its control is at the level of gene transcription. The inducible inflammatory gene expression programme - such as that triggered by Toll-like receptor signalling in macrophages - is comprised of several coordinately regulated sets of genes that encode key functional programmes; these are controlled by three classes of transcription factors, as well as various transcriptional co-regulators and chromatin modifications. Here, we discuss the mechanisms of and the emerging principles in the transcriptional regulation of inflammatory responses in diverse physiological settings.
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