Journal
NATURE REVIEWS CANCER
Volume 9, Issue 5, Pages 361-371Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2628
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Funding
- Medical Research Council [G0501974] Funding Source: Medline
- MRC [G0501974] Funding Source: UKRI
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Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to harness this anti-tumour activity in cancer treatments were underway, a paradoxical tumour-promoting role of TNF became apparent. Now that links between inflammation and cancer are appreciated, is TNF a target or a therapeutic in malignant disease - or both?
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