Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 5, Pages 338-352Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2536
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Funding
- Cancer Research Institute Elaine R. Shephard Award (USA)
- Mizutani Foundation for Glycoscience (Japan)
- Prostate Cancer Foundation (UK)
- Fundacion Sales (Argentina)
- Agencia Nacional de Promocion Cient fica y Tecnologica [2006-603]
- Universidad de Buenos Aires [M091]
- Consejo Nacional de Investigaciones Cient ficas y Tecnicas (Argentina)
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The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine-containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.
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