Journal
NATURE REVIEWS CANCER
Volume 9, Issue 5, Pages 327-337Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2608
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Funding
- National Cancer Institute [CA82313, CA21765]
- American Lebanese Syrian Associated Charities (ALSAC)
- NATIONAL CANCER INSTITUTE [R01CA082313, P30CA021765, R01CA052814] Funding Source: NIH RePORTER
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DNA topoisomerases are enzymes that disentangle the topological problems that arise in double-stranded DNA. Many of these call be solved by the generation of either single or double strand breaks. However, where there is a clear requirement to alter DNA topology by introducing transient double strand breaks, only DNA topoisomerase II (TOP2) can carry out this reaction. Extensive biochemical and structural Studies have provided detailed models of how TOP2 alters DNA structure, and recent molecular studies have greatly expanded knowledge of the biological contexts in which TOP2 functions, Such as DNA replication, transcription and chromosome segregation - processes that are essential for preventing tumorigenesis.
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