Journal
NATURE REVIEWS IMMUNOLOGY
Volume 9, Issue 12, Pages 883-889Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2660
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Funding
- United States National Institutes of Health [AI35783, AI57956, DK71176]
- University of Alabama at Birmingham Mucosal HIV and Immunobiology Center
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI057956, R01AI035783, R21AI035783] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK071176] Funding Source: NIH RePORTER
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The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota.
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