Journal
BULLETIN OF MATHEMATICAL BIOLOGY
Volume 76, Issue 4, Pages 799-818Publisher
SPRINGER
DOI: 10.1007/s11538-013-9844-3
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Funding
- European Research Council under the European Community [239870]
- Brasenose College, University of Oxford
- Royal Society for a University Research Fellowship
- National Science Foundation CAREER Award [CHE-0846701]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1119958] Funding Source: National Science Foundation
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Two multiscale (hybrid) stochastic reaction-diffusion models of actin dynamics in a filopodium are investigated. Both hybrid algorithms combine compartment-based and molecular-based stochastic reaction-diffusion models. The first hybrid model is based on the models previously developed in the literature. The second hybrid model is based on the application of a recently developed two-regime method (TRM) to a fully molecular-based model, which is also developed in this paper. The results of hybrid models are compared with the results of the molecular-based model. It is shown that both approaches give comparable results, although the TRM model better agrees quantitatively with the molecular-based model.
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