Journal
BULLETIN OF MATHEMATICAL BIOLOGY
Volume 73, Issue 12, Pages 3008-3029Publisher
SPRINGER
DOI: 10.1007/s11538-011-9657-1
Keywords
Mathematical modelling; HTLV-I; Persistent viral infection; Latently infected target cells; Viral tax protein; Global stability; Backward bifurcation
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Funding
- NSERC PGSM
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Foundation for Innovation (CFI)
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Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease, and adult T-cell leukemia (ATL). Chronically infected individuals often harbor high proviral loads despite maintaining a persistently activated immune response. Based on a new hypothesis for the persistence of HTLV-I infection, a three-dimensional compartmental model is constructed that describes the dynamic interactions among latently infected target cells, target-cell activation, and immune responses to HTLV-I, with an emphasis on understanding the role of Tax expression in the persistence of HTLV-I.
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