Journal
BULLETIN OF MATERIALS SCIENCE
Volume 37, Issue 4, Pages 945-951Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12034-014-0030-5
Keywords
Methotrexate; PLGA 50:50; nanoparticles; cytotoxic activity
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Funding
- Department of Biotechnology, Ministry of Science and Technology, Government of India [BT/PR10830/NNT/28/114/2008]
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Nanoparticles represent one of the attractive alternatives in the effective treatment of cancer chemotherapy. In the present work, formulation and development of a novel methotrexate (MTX)-loaded biodegradable nanoparticles using poly(D,L-lactide-co-glycolide) (PLGA) was carried out. The prepared nanoparticles were evaluated for physicochemical properties such as particle size, zeta potential, release studies, etc and also evaluated for its in vitro cytotoxic potential against U-343 MGa human neuronal glioblastoma cells. Particle size of optimized formulation was <200 nm. There was a considerable decrease in cell viability and enhancement in cytotoxic activity of MTX-loaded nanoparticles compared to MTX alone when tested against U-343 MGa human neuronal glioblastoma cells.
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