Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 157, Issue 4, Pages 524-529Publisher
SPRINGER
DOI: 10.1007/s10517-014-2606-x
Keywords
cisplatin; nanogels; targeted delivery; monoclonal antibodies to connexin-43; brain tumors
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Funding
- Russian Federation for Young Scientists [MK-7114.2012.7]
- Ministry of Education and Science of the Russian Federation [11G34.31.0004]
- Russian Foundation for Basic Research [12-04-31731]
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The aim of this study was to create a nanocontainer conjugated with monoclonal antibodies to connexin 43 (Cx43) that is actively expressed at the periphery of C6 glioma and in the astroglia roll zone. Stable vector nanogels with high (up to 35%) cisplatin load were synthesized. The antitumor effects of Cx43-modified cisplatin-loaded nanogels, free cisplatin, and nonspecific drugs were carried out on C6 glioma model. Vector nanogels reduced systemic toxicity of cisplatin, effectively inhibited tumor growth, and significantly prolonged the lifespan of animals with experimental tumors.
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