Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 157, Issue 1, Pages 103-107Publisher
SPRINGER
DOI: 10.1007/s10517-014-2502-4
Keywords
preeclampsia; placenta; insulin-like growth factor (IGF); insulin-like growth factor binding protein-3 (IGFBP-3)
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Funding
- Russian Federation [MK-1294.2012.7]
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Comparative morphological study of the placentas in women with preeclampsia and smallfor-date fetuses was carried out. Expression of insulin-like growth factor-1 (IGF-1), insulinlike growth factor-2 (IGF-2), and insulin-like growth factor binding protein-3 (IGFBP-3) was detected by immunohistochemical methods. Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected. The most pronounced changes were found in preeclampsia associated with small-for-date fetuses.
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