Content of IL-10 and CD4+CD210+ Cells in Mice with Adjuvant Arthritis before and after Treatment with Cryopreserved Placental Cells

We analyzed the serum level of IL-10, blood content of CD4(+)D210(+) cells, and expression of IL-10 receptors in adjuvant arthritis before and after treatment with native and cryopreserved placental cells. In animals with experimental adjuvant arthritis, a negative correlation was found between the index of arthritis and IL-10 concentration (r=-0.7; p=0.03); in addition, a considerable decrease in the content of CD4(+)CD210(+) cells and changes in the expression of IL-10 receptors on cells of the lymph nodes and spleen were demonstrated. After administration of cryopreserved DMSO-protected placental cells (in contrast to administration of cryopreserved propanedioxysacharol-protected cell suspension), the content of CD4(+)CD210(+) cells in the spleen of animals with experimental adjuvant arthritis returned to normal.