Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 154, Issue 3, Pages 316-319Publisher
SPRINGER
DOI: 10.1007/s10517-013-1940-8
Keywords
calmodulin; calmodulin-dependent kinase; PP2A phosphatase
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Funding
- Russian Foundation for Basic Research [0-04-01023-a]
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Calmodulin inhibitor W-7 did not cause changes in the quantal content of postsynaptic endplate potentials (EPP) in newly formed synapses, but prevented facilitation of acetylcholine secretion induced by L-type Ca2+ channels blocker nitrendipine. CaMKII inhibitor KN-62 produced similar effect and suppressed the increase in EPP quantal content caused by blockade of L-type Ca2+ channels. Phosphatase PP2A inhibitor okadaic acid significantly facilitated secretion in newly formed synapses; the effect was completely blocked by KN-62. In mature synapses, okadaic acid had no effect on transmitter secretion. KN-62 increased EPP quantal content. We hypothesize that CaMKII produced different effects on acetylcholine secretion in mature and immature synapses depending on specificity of calcium signaling and PP2A phosphatase activity.
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