Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 155, Issue 6, Pages 798-801Publisher
SPRINGER
DOI: 10.1007/s10517-013-2255-5
Keywords
pancreatic islets; morphogenesis; insulin; glucagon; co-location
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Funding
- Fundamental specialized foundation for research support in biology and medicine
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Various types of insulin- and glucagon-containing endocrine cell distribution were found by double staining with antibodies to insulin and glucagon in the pancreatic autopsy material from subjects without carbohydrate metabolism disorders. The cell composition of the islets and their morphogenetic maturity depended on the vascularization degree. Insulin-containing cells predominated in small clusters of endocrine cells and in islets with few capillaries, while glucagon predominated in large islets with rich vascularization. A scheme of development and differentiation of Langerhans islets in the adult human pancreas was presented.
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