The Mechanism of Cytostatic Effect of a New Somatostatin Analog Cifetrelin on In Vitro Cultured MCF-7 Breast Carcinoma Cells

The mechanisms of antitumor effect of cifetrelin have been studied in vitro on cultured MCF-7 breast carcinoma cells. Cifetrelin exhibits higher cytotoxic activity than native somatostatin. In subthreshold concentrations, cifetrelin boosts the apoptotic effects of drugs, e.g. adriamycin. Cifetrelin-induced apoptosis develops by the p53-independent mechanism and is associated with early suppression of NF-kappa B activity. These data attest to high antitumor activity of cifetrelin.