Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 152, Issue 6, Pages 731-733Publisher
SPRINGER
DOI: 10.1007/s10517-012-1618-7
Keywords
dimebon; neurodegeneration; synucleins; transgenic animals
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Funding
- Russian Foundation for Basic Research [09-04-01412-a]
- Board of the Russian Academy of Sciences
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Aggregation of proteins liable to assembling into fi brils with subsequent formation of amyloid incorporations is an important component in the pathogenesis of many neurodegenerative diseases. Dimebon, a Russian drug, reduces the content of detergent-insoluble fi brillar forms of synuclein, the main protein component of pathological incorporations in neurons of transgenic mouse strain used in the study.
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