Study of High-Resolution H1 Nuclear Magnetic Resonance Spectra of the Serum and Its Albumin Fraction in Patients with the First Schizophrenia Episode

We studied high-resolution H-1 nuclear magnetic resonance spectra of the serum and serum albumin from patients with the fi rst episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH2 protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH2 and CH3 protons of non-esterifi ed fatty acids were found in H-1 nuclear magnetic resonance spectra of serum albumin. These data attest to an essential role of changes in lipid metabolism and changed ligand load of albumin in schizophrenia.