Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 152, Issue 6, Pages 748-751Publisher
SPRINGER
DOI: 10.1007/s10517-012-1622-y
Keywords
H-1 nuclear magnetic resonance spectroscopy; serum; lipids; albumin; first episode of schizophrenia
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Funding
- International Research and Technology Center [3156]
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We studied high-resolution H-1 nuclear magnetic resonance spectra of the serum and serum albumin from patients with the fi rst episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH2 protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH2 and CH3 protons of non-esterifi ed fatty acids were found in H-1 nuclear magnetic resonance spectra of serum albumin. These data attest to an essential role of changes in lipid metabolism and changed ligand load of albumin in schizophrenia.
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