Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 150, Issue 4, Pages 406-408Publisher
SPRINGER
DOI: 10.1007/s10517-011-1153-y
Keywords
alpha-synuclein; macrophages; dopaminergic neurons
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Funding
- analytical department purpose-oriented program Development of Higher School Scientific Potential [2.1.1/3695]
- Russian Foundation Basic Researches [10-04-00246-a]
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Administration of autologous macrophages isolated from the abdominal cavity and stimulated in vitro with bacterial LPS to rats increased blood level of antibodies against alpha-synuclein. Antibody titer reached its maximum during week 5 of the experiment and exceeded the levels of anti-alpha-synuclein antibodies appeared in response to transplantation of non-stimulated macrophages. Brain immunohistochemistry showed that additional administration of LPS (250 mu g/kg) to animals during week 4 after injection of LPS-stimulated macrophages led to alpha-synuclein accumulation in 9.4 +/- 3.2% dopaminergic neurons of the substantia nigra. These findings attest to induction of humoral immune response to alpha-synuclein in rats after administration of autologous LPS-stimulated macrophages, which can affect alpha-synuclein metabolism in dopaminergic neurons of the brain.
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