Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 151, Issue 6, Pages 702-704Publisher
SPRINGER
DOI: 10.1007/s10517-011-1420-y
Keywords
apoptosis; hydrogen sulfide; caspases
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Funding
- Federal Target Program Scientific and scientific-pedagogical personnel of innovative Russia [02.740.11.0311]
- Development of the technology for selective regulation of intracellular gas signaling project [02.740.11.5031]
- Role of intracellular gas transmitters in the regulation of cell homeostasis project [P1311]
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We studied the effect of a gas transmitter hydrogen sulfide (H(2)S) on the realization of apoptosis in Jurkat cells and mononuclear leukocytes from healthy donors. Treatment with H(2)S donor NaHS was accompanied by a dose-dependent intensification of cell death via apoptosis and necrosis. T-cell leukemia cells were more sensitive to H(2)S than mononuclear leukocytes from healthy donors. H(2)S-induced cell apoptosis was accompanied by activation of caspase-3 and caspase-9.
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