Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 151, Issue 4, Pages 436-439Publisher
SPRINGER
DOI: 10.1007/s10517-011-1350-8
Keywords
gold nanoparticles; transmissible gastroenteritis virus; immunization; macrophages; interferon
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Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respiratory activity and of plasma IFN-gamma level in immunized animals.
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