Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 150, Issue 1, Pages 1-5Publisher
SPRINGER
DOI: 10.1007/s10517-010-1052-7
Keywords
isolated cardiomyocytes; whole-cell ionic currents; mechanically gated channels; NO-donors
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Funding
- Russian Foundation for Basic Research [09-04-01277-a]
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Whole-cell ionic currents through mechanically gated chnnels (MGC) were recorded in isolated cardiomyocytes under voltage clamp conditions. In unstrained cells, NO donors SNAP and DEA-NO activated MGC and induced MG-like currents. In contrast, in stretched cells with activated MGC, these NO-donors inactivated and inhibited MGC.
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