Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 150, Issue 1, Pages 18-22Publisher
SPRINGER
DOI: 10.1007/s10517-010-1057-2
Keywords
inhibitors of nitric oxide synthesis; in vivo electron paramagnetic resonance spectroscopy with a NO spin trap; isothiourea derivatives; hypovolemic shock; antihypotensive effect
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Funding
- State Budget [0120.0 602187]
- Russian Foundation for Basic Research
- Administration of the Kaluzhskaya oblast [07-04-97607]
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In vivo effect of isothiourea derivatives on NO production was studied by the method of electron paramagnetic resonance spectroscopy with a spin trap. We evaluated the influence of these compounds on hemodynamic parameters in anesthetized rats with hypovolemic shock. A correlation was found between the size of S, N-substituents in isothiourea derivatives (methyl, ethyl, and isopropyl) and NO inhibitory activity of compounds. The antihypotensive effect was more pronounced in compounds with high NO inhibitory activity containing the isopropyl radical.
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