Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 150, Issue 1, Pages 65-67Publisher
SPRINGER
DOI: 10.1007/s10517-010-1070-5
Keywords
lifespan; Drosophila melanogaster; phenol antioxidant
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Funding
- Russian Foundation for Basic Research [07-04-00166, 09-04-00600]
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The effect of hydrophilic synthetic antioxidant TC-13 (3-(3'-tert-butyl-4'-hydroxyphenyl) propylthiosulfonate sodium) inducing the antioxidant-responsive element on the lifespan of Drosophila melanogaster was studied. Addition of 1% TC-13 to diets prolonged the lifespan of long-lived D. melanogaster Canton S strain females and males, but not of short-lived Oregon R insects and reduced the mean lifespan of D. melanogaster males of the lgl(558)OR/Cy strain containing a recessive lethal mutation of tumor suppressor in the heterozygotic state. The geroprotective effects of TC-13 synthetic phenol antioxidant depended on D. melanogaster genotype and gender.
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