Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 146, Issue 3, Pages 328-333Publisher
SPRINGER
DOI: 10.1007/s10517-008-0267-3
Keywords
fucoidans; anticoagulant activity; thrombin; factor Xa
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Funding
- Russian Foundation for Basic Research [05-04-08100-ofi-a, 05-03-32883-a, 06-04-48540, 06-04-08140-ofi, 07-04-12112-ofi]
- Siberian Division of Russian Academy of Medical Sciences and Far Eastern Division of Russian Academy of Sciences [05-II-SM-05-007, 06-II-SM-05-004]
- Russian Academy of Sciences
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Specimens of fucoidan extracted from Fucus evanescens were purified from protein and polyphenols, deacetylated and depolymerized by fucoidanase for evaluation of their biological activity. Deacetylation did not modify the capacity of fucoidan to inhibit thrombin and factor Xa, while purification from protein and polyphenols reduced this capacity. Depolymerization of fucoidan increased its capacity to inhibit thrombin mainly through heparin cofactor II. All the studied specimens formed complexes with protamine sulfate.
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