Journal
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
Volume 82, Issue 4, Pages 411-414Publisher
SPRINGER
DOI: 10.1007/s00128-008-9591-6
Keywords
Nitroimidazoles; LC-APCI-MS; Swine liver
Categories
Funding
- Natural Science Foundation of China [20621703]
- Foundation of Ministry of Science & Technology of China [2002BA906A75]
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A liquid chromatography-mass spectrometry method was developed for the simultaneous determination of ronidazole (RNZ), metronidazole (MNZ) and dimetridazole (DMZ) residues in swine liver. Following liquid-liquid extraction, the HLB solid-phase extraction was used for further purification. The targets were detected by atmospheric pressure chemical ionization (APCI) following the reverse phase liquid chromatography separation. Consequently, the detection limits for the method were 0.5 mu g/kg for MNZ, 1.0 mu g/kg for RNZ and 0.5 mu g/kg for DMZ, respectively. The accuracies were determined using swine liver samples fortified at levels of 0.5, 1, 2, and 4 mu g/kg and the mean recoveries of the analytes were between 66% and 81%.
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