Anti-inflammatory activity of methanolic extracts of Dillenia indica L. leaves

The anti-inflammatory activities of the methanol extract of Dillenia indica Linnaeus (Family Dilleniaceae) leaves were observed in various experimental models related to inflammation to provide some evidence for its traditional use. Anti-inflammatory activity was observed in carrageenan-induced edema and acetic acid-induced capillary permeability. The methanol extract showed signiflcant (P<0.01) anti-inflammatory activity in the paw edema test and acetic acid-induced capillary permeability at 200 mg/kg and 400 mg/kg. The extract at 100 mg/kg showed significant (P<0.05) activity in acid-induced permeability. These findings support the folkloric use of Dillenia indica in diseases related to inflammatory conditions.