Journal
SLEEP MEDICINE CLINICS
Volume 4, Issue 2, Pages 213-+Publisher
ELSEVIER INC
DOI: 10.1016/j.jsmc.2009.01.009
Keywords
Circadian; Rhythm; Neurodegeneration; Alzheimer's disease; Irregular
Categories
Funding
- NIH [AG025515, AG031126, MH072736, NR001094, CA116400, AG11412, HL069988, HL086461]
- NATIONAL CANCER INSTITUTE [R01CA116400] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000048] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL086461, R01HL090873, R01HL069988] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH072736] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NURSING RESEARCH [R01NR001094] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG031126, P01AG011412, R01AG025515] Funding Source: NIH RePORTER
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Irregular sleep-wake rhythm disorder (ISWRD) is characterized by the relative absence of a circadian pattern in an individual's sleep-wake cycle. ISWRD is thought to result from some combination of degeneration or decreased neuronal activity of suprachiasmatic nucleus neurons, decreased responsiveness of the circadian clock to entraining agents such as light and activity, and decreased exposure to bright light and structured social and physical activity during the day. Studies of the effectiveness of pharmacologic treatments for ISWRD generally have yielded negative or inconsistent results. In general multimodal nonpharmacologic approaches involving increased exposure to light, increased physical and social activities, and improved sleep hygiene have been the most successful therapeutic approaches.
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