Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 37, Issue 4, Pages 171-178Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e3181b7b932
Keywords
rehabilitation; epidural stimulation; pharmacological interventions; spinal learning; locomotor training; sensorimotor plasticity
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Funding
- NIH [NIH NS42291, NIH NS54159, RFBR-CRDF 07-04-91106]
- Christopher and Diana Reeve Foundation
- California Roman Reed Bill
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB007615] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS016333, R01NS054159, R01NS042291] Funding Source: NIH RePORTER
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EDGERTON, V.R. and R.R. ROY. Activity-dependent Plasticity of spinal locomotion: implications for sensory processing. Exerc. Sport Sci. Rev., Vol. 37, No. 4, Pp. 171-178, 2009. The lumbosacral spinal cord of mammals contains the neural circuitry capable of generating full weight-bearing locomotion of the hind limbs without any supraspinal input. One or more interventions, for example, pharmacological, epidural stimulation, and/or locomotor training, however, are necessary to gain access to and modulate the properties of this circuitry and to facilitate recovery of full weight-bearing locomotion after spinal cord injury.
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