Journal
TRAUMA VIOLENCE & ABUSE
Volume 10, Issue 4, Pages 389-410Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1524838009339758
Keywords
stress; corticotrophin releasing factor; development; cortisol; abuse
Categories
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH042088, P50MH077083, U19MH069056, R01MH039415, P50MH058922, R37MH039415] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH 077083, MH 069056, R01 MH042088, MH 42088, R01 MH039415, MH 039415, U19 MH069056, P50 MH058922, P50 MH077083, K23 MH082256, MH 058922] Funding Source: Medline
- NINDS NIH HHS [F32 NS054535] Funding Source: Medline
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Exposure to interpersonal violence or abuse affects the physical and emotional well-being of affected individuals. In particular, exposure to trauma during development increases the risk of psychiatric and other medical disorders beyond the risks associated with adult violence exposure. Alterations in the hypothalamic-pituitary-adrenal (HPA) axis, a major mediating pathway of the stress response, contribute to the long-standing effects of early life trauma. Although early life trauma elevates the risk of psychiatric and medical disease, not all exposed individuals demonstrate altered HPA axis physiology, suggesting that genetic variation influences the consequences of trauma exposure. In addition, the effects of abuse may extend beyond the immediate victim into subsequent generations as a consequence of epigenetic effects transmitted directly to offspring and/or behavioral changes in affected individuals. Recognition of the biological consequences and transgenerational impact of violence and abuse has critical importance for both disease research and public health policy.
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