Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 201, Issue 1, Pages 33-39Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.111.100594
Keywords
-
Categories
Funding
- Medical Research Council studentship
- Wellcome Trust Value In People award
- GlaxoSmithKline UK
- National Institute of Health Research Biomedical Research Centre for Mental Health at South London
- Maudsley National Health Service Foundation Trust
- King's College London, Institute of Psychiatry, UK
- Medical Research Council [G9817803B] Funding Source: researchfish
Ask authors/readers for more resources
Background White matter abnormalities have been implicated in the aetiology of major depressive disorder; however, the relationship between the severity of symptoms and white matter integrity is currently unclear. Aims To investigate white matter integrity in people with major depression and healthy controls, and to assess its relationship with depressive symptom severity. Method Diffusion tensor imaging data were acquired from 66 patients with recurrent major depression and a control group of 66 healthy individuals matched for age, gender and IQ score, and analysed with tract-based spatial statistics. The relationship between white matter integrity and severity of depression, as measured by the Beck Depression Inventory was examined. Results Depressive illness was associated with widespread regions of decreased white matter integrity, including regions in the corpus callosum, superior longitudinal fasciculus and anterior corona radiata, compared with the control group. Increasing symptom severity was negatively correlated with white matter integrity, predominantly in the corpus callosum. Conclusions Widespread alterations in white matter integrity are evident in major depressive disorder. These abnormalities are heightened with increasing severity of depressive symptoms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available