Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 198, Issue 6, Pages 424-427Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.110.085225
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Funding
- Medical Research Council [G9817803B] Funding Source: researchfish
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The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.
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