Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 196, Issue 6, Pages 425-426Publisher
ROYAL COLLEGE OF PSYCHIATRISTS
DOI: 10.1192/bjp.bp.109.074880
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Funding
- Economic and Social Research Council [ES/E00234X/1, ES/G007489/1] Funding Source: researchfish
- ESRC [ES/E00234X/1] Funding Source: UKRI
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Cigarette smokers frequently describe the anxiolytic and antidepressant effects of smoking, but evidence suggests that cigarette smoking may itself increase negative affect, so that the causal direction of this association remains unclear. Although increasingly sophisticated analyses of epidemiological data may help to answer this question, observational data can never unequivocally provide evidence of causation. Here we discuss the potential utility of genetic information in determining the causal basis of the relationship of cigarette smoking and depression.
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