Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 194, Issue 2, Pages 139-145Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.107.047993
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Funding
- Stanley Medical Research Institute
- Medical Research Council
- Esther Yewpick Lee Millennium Scholarship
- Hruska Scholarship
- Medical Research Council [G1002025] Funding Source: researchfish
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Background Depression is associated with neural abnormalities in emotional processing. Aims This study explored whether these abnormalities underlie risk for depression. Method We compared the neural responses of volunteers who were at high and low-risk for the development of depression (by virtue of high and low neuroticism scores; high-N group and low-N group respectively) during the presentation of fearful and happy faces using functional magnetic resonance imaging (fMRI). Results The high-N group demonstrated linear increases in response in the right fusiform gyrus and left middle temporal gyrus to expressions of increasing fear, whereas the low-N group demonstrated the opposite effect. The high-N group also displayed greater responses in the right amygdala, cerebellum, left middle frontal and bilateral parietal gyri to medium levels of fearful v. happy expressions. Conclusions Risk for depression is associated with enhanced neural responses to fearful facial expressions similar to those observed in acute depression.
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