Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 194, Issue 4, Pages 373-374Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.108.055459
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Funding
- Netherlands Organisation for Scientific Research (NWO)
- Wellcome Trust
- Psychiatry Research Trust
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This study examined brain activation during a cognitive inhibition task in patients with schizophrenia following changes in their positive symptoms. A Stroop task was used during functional magnetic resonance imaging in 11 patients with schizophrenia (patient group) and 9 healthy volunteers (control group). At baseline, the patient group showed significantly attenuated activation within the anterior cingulate gyrus, left pre-/postcentral gyrus and inferior frontal junction. At follow-up, there was a significant increase in activation in the left inferior frontal junction associated with a decrease in positive symptoms, suggesting this region plays a role in the development of these symptoms.
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