Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 193, Issue 4, Pages 316-321Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.107.045120
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Ministry of Health, Labour and welfare, Japan [19KOU-3]
- [18591280]
- [14370288]
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Background Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability. Aims To test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability). Method A case-control study was conducted in Japan. The participants consisted of individuals with full-scale IQ >= 70, with a DSM-IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order. Results Eighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates. Conclusions Advanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.
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