Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 193, Issue 2, Pages 126-129Publisher
ROYAL COLLEGE OF PSYCHIATRISTS
DOI: 10.1192/bjp.bp.107.048793
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIBIB NIH HHS [R01EB006494, R01 EB006494] Funding Source: Medline
- NIDA NIH HHS [PL1 DA024859, PL1 DA024859-02] Funding Source: Medline
- NIMH NIH HHS [R01 MH069747-02, R01 MH069747, R01 MH070902, R01MH69747, R01 MH069747-01A1, R01 MH070902-03, R01MH070902, R01 MH070902-01A1, R01 MH070902-02, R01 MH069747-03] Funding Source: Medline
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Background Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder. Aims To test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum. Method Fractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging. Results Fractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups. Conclusions Our findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum.
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